Memorial Sloan Kettering Cancer Center, Genentech and BioNTech are pioneering a novel approach to pancreatic cancer treatment with a personalized mRNA vaccine. This vaccine is tailored to target each patient's tumor's genetic peculiarities, using the body's defense mechanism. The technique seeks to alter the landscape of cancer treatment significantly and is currently under a phase 2 trial. The vaccine works by interacting with neoantigens, triggering T cells to recognize them as foreign, thereby inciting a strong immune response. It primes the immune system, enhances its recognition of cancer cells, and stimulates dendritic cells to guide T cells to attack tumor cells. This groundbreaking strategy could potentially provide a sustainable immune defense against pancreatic cancer and redefine the future of precision oncology.
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